Thursday, November 13, 2008

Vaccine Preparation

Shake vial vigorously to obtain a uniform suspension prior to withdrawing each dose. Whenever solution and container permit, inspect vaccine visually for particulate matter and/or discoloration prior to administration. If problems are noted (e.g., vaccine cannot be resuspended), the vaccine should not be administered.

Reconstitute just before using. Use only the diluents supplied with the vaccine. Inject the volume of the diluents shown on the diluents label into the vial of lyophilized vaccine and gently agitate to mix thoroughly. Withdraw the entire contents and administer immediately after reconstitution.
Discard single dose MPSV4, varicella, and zoster vaccines if not used within 30 minutes after reconstitution.
 
Note: Unused reconstituted MMR vaccine and multidose MPSV4 vaccine may be stored at 35–46°F (2–8°C) for a limited time. The reconstituted MPSV4 vaccine must be used within 35 days; the reconstituted MMR vaccine must be used within 8 hours. Do not freeze either reconstituted vaccine.
 
Always refer to the package insert included with each biologic for complete vaccine administration information. CDC's Advisory Committee on Immunization. Practices (ACIP) recommendations for the particular vaccine should be reviewed as well.

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